Structural basis for activity of TRIC counter-ion channels in calcium release
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چکیده
منابع مشابه
Structural basis for conductance through TRIC cation channels
Mammalian TRICs function as K+-permeable cation channels that provide counter ions for Ca2+ handling in intracellular stores. Here we describe the structures of two prokaryotic homologues, archaeal SaTRIC and bacterial CpTRIC, showing that TRIC channels are symmetrical trimers with transmembrane pores through each protomer. Each pore holds a string of water molecules centred at kinked helices i...
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Calcium Regulation of Ion Channels in Neurons
Intracellular calcium modulates the activity of a number of voltagedependent ion channels in neurons. This modulation is often functionally important, and can influence the responsiveness of cells to natural inputs. In extreme cases, the regulation of ion channels by intracellular calcium can even determine the pattern of electrical activity of neurons. In this review, I will summarize the role...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2019
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1817271116